Ovarian Cancer Might Not Start Where We Think It Does


Ovarian Cancer Might Not Start Where We Think It Does


The usual believe is that ovarian cancer begin in the ovaries. But recent study have found that ovarian cancer might not originate in ovaries, Instead, ovarian cancer may, in fact, begin in the Fallopian tubes.

The study, is published in Nature Communications.In the study, the researcher  looked at various cancerous and noncancerous tissue samples from nine women, five of whom had high-grade serous carcinoma — the most common type of ovarian cancer — and the rest four of them had their ovaries removed due to being at high risk of developing ovarian cancer, like actress Angelina Jolie did.


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The research, which is still in early stages, showed serious tubal intraepithelial carcinoma lesions in the fallopian tubes of all nine women, which the researchers called precursors to ovarian cancer.

“The subsequent formation of a cancer in the ovaries represents a seeding event from a primary tumor in the Fallopian tubes,” the study says.

“If studies in larger groups of women confirm our finding that the fallopian tubes are the site of origin of most ovarian cancer, then this could result in a major change in the way we manage this disease for patients at risk,” senior researcher Victor Velculescu from the Johns Hopkins Kimmel Cancer Center in Maryland said in a statement.


Then again, Using statistical models, the researchers found that cancer developed at an average of 6.5 years afterward the lesions developed. But once the cancer reaches the ovaries, it only takes 2 years to quickly progress to a metastatic disease, and spreads to different areas of the body.

SO, more studies are needed with a broad range of samples to confirm this. But this study is just the first steps to discovering more about ovarian cancer.

Ovarian cancer (OC) is the seventh most commonly diagnosed cancer among women in the world. This cancer is the number one cause of death from gynecological cancers and its survival rate has not improved over the past 30 years. Less than 30% of women survive beyond 10 years. The main reason for this is because the cancer is detected mostly later stage. So, if it can be found where the disease specifically starts then the survival rate could improve a lot.


Adopted from: New York Daily News

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